Independent toxicological evaluation
Signed assessments of ingredient and finished-product safety. Hazard characterization, dose–response review, and uncertainty analysis structured for regulator and retailer scrutiny.
Independent toxicological evaluation · Exposure-based risk
Exposure-based risk assessment, defensible substantiation, and regulatory alignment across U.S. and EU frameworks. The Agyekum Group (AG) conducts independent toxicological evaluations for cosmetics, personal care, fragrances, ingestibles, and consumer goods — documented for regulatory review, retail compliance, and enforcement-relevant decision-making.
We work with startup, emerging, and enterprise companies across cosmetics, personal care, fragrance, and ingestible categories. Engagements are entered in a selective advisory capacity for brands, platforms, scientific initiatives, and product-safety governance programs.
Platform access available below.
Toxicology intelligence layer
Exposure-based safety evaluation, regulatory intelligence, formulation review, and scientific risk assessment — delivered through ToxIntel, the Aᴳ platform for independent consultants, growing brands, manufacturers, retailers, and legal teams.
Practice capabilities
Five practice areas anchor every engagement. Each is signed by a named toxicologist and documented for the next reader — regulator, retailer, or court.
Signed assessments of ingredient and finished-product safety. Hazard characterization, dose–response review, and uncertainty analysis structured for regulator and retailer scrutiny.
Quantitative SED / NOAEL / MoS / BMD analyses per population band. Pathway-specific exposure modelling for dermal, oral, inhalation, and mucosal use.
Product-level safety substantiation across cosmetics, personal care, fragrance, ingestibles, and adjacent consumer categories — fit for MoCRA, EU 1223, and IFRA contexts.
Toxicology-led regulatory strategy and litigation-aware documentation. Independent expert review, Prop 65 exposure framing, and enforcement-relevant scientific narrative.
Aᴳ’s in-house platform — contaminant surveillance, formulation review, compliance passport export, and continuously updated regulatory context. Made available to enterprise clients.
Federal Register, FDA, CPSC, OEHHA, and FTC signals tracked and interpreted — surfaced below in Toxicology Watch and integrated into client briefings.
Frameworks & methodology
Every Aᴳ evaluation references the same regulatory frameworks and scientific methodologies a competent authority, retailer, or court would reference. We are explicit about which framework applies, where its boundary lies, and what evidence the engagement produces.
Regulatory frameworks
Modernization of Cosmetics Regulation Act
U.S. cosmetic facility & product registration, adverse-event reporting, safety-substantiation evidence requirements.
Regulation (EC) No 1223/2009
Cosmetic Product Safety Reports (CPSR), responsible-person obligations, Annex II/III/IV/V/VI ingredient controls.
Safe Drinking Water and Toxic Enforcement Act
Exposure-based assessment vs Safe Harbor Levels; warning-decision logic; NSRL / MADL framing.
EU Scientific Committee on Consumer Safety
Authoritative EU opinions on cosmetic ingredients; SCCS Notes of Guidance methodology baseline.
International Fragrance Association
Fragrance-ingredient use restrictions, dermal sensitization QRA, category-specific limits.
Scientific frameworks
SED · MoS · BMD methodology
Quantitative dermal, oral, inhalation, and mucosal exposure modelling per population band.
NOAEL / LOAEL → MoS
Internal-dose modelling against point-of-departure values; uncertainty factor selection and justification.
Hazard characterization
Acute, subchronic, and chronic endpoint review across genotoxicity, sensitization, irritation, repro/dev, and systemic toxicity.
WoE evaluation
Structured integration of human, animal, in-vitro, and in-silico data streams with study-quality weighting.
Claim & label substantiation
Defensible documentation of safety, performance, and regulatory claims for retailer and litigation contexts.
All assessments are signed by a named toxicologist · documented for regulatory, retailer, and litigation contexts.
01 — Scope
Toxicology and risk assessment aligned with EU, FDA, and international frameworks where safety substantiation and exposure analysis are required.
Evaluation of formulations and ingredients against exposure-based safety criteria and documentation standards applied in retailer governance.
Independent toxicological analysis of chemical exposure, dose–response, causation, and complex data — structured to withstand legal scrutiny.
Hazard characterization, exposure considerations, and regulatory status review of ingredients in support of downstream use.
02 — Services
Every engagement is led personally, signed off in writing, and structured for regulatory inspection, retailer review, and enforcement-relevant decision-making.
Independent toxicological evaluation and exposure-based risk assessment for cosmetic and personal care products across all categories.
Exposure-based safety evaluation and governance suitable for third-party review across dietary supplements and ingestible wellness products.
Exposure-based risk assessment for fragrance ingredients and finished blends, including sensitization potential and IFRA alignment.
Defensible toxicological evaluation supporting MoCRA safety substantiation, adverse-event frameworks, and inspection-ready documentation.
Quantitative exposure assessment and regulatory strategy for Proposition 65–listed substances across consumer products.
Exposure-driven safety assessment for brands navigating PFAS in consumer products and materials, multi-jurisdiction aware.
Toxicology-first study design. Every protocol must reduce uncertainty and align with intended use conditions.
Hazard characterization and risk-based screening of raw materials and functional components — including scrutinized substances.
03 — Philosophy
Testing volume is increasing. The differentiator is not how much testing is performed — it is whether the data meaningfully reduces uncertainty and strengthens governance. Before recommending or reviewing any protocol, we define the decision:
04 — Practice lead
No anonymous reports, no offshored interpretation. Aᴳ is led personally by Dr. Augustine K. Agyekum, with specialist advisors engaged per assignment.
Founder · Independent Toxicologist
"Dr. Kwaku"
Founder of Aᴳ, an independent scientific consulting firm specialising in cosmetic and consumer product safety. Dr. Agyekum advises brands, manufacturers, and legal teams on ingredient safety, quantitative risk assessment, and compliance with FDA MoCRA, the EU Cosmetics Regulation, IFRA standards, and California Prop 65 — translating complex toxicological data into clear safety decisions.
Advisory roster
Aᴳ engages specialist advisors on a per-assignment basis — drawing on board-certified toxicologists, regulatory scientists, and analytical chemists when an engagement warrants additional depth. Roster details available on request.
05 — Engage
Send a short brief — product, jurisdictions, timeline, and the regulatory question that prompted the call. We respond within two business days.
Direct line
regulatory@tagc.us linkedin.com/company/the-agyekum-groupPractice
The Agyekum Group (AG)
Independent toxicology
Engagements
Cosmetics · Personal care
Ingestibles · Fragrance
Jurisdictions
EU · UK · US (FDA / MoCRA)
California Prop 65 · APAC
Platform
Platform Access →06 — Toxicology Watch
Aggregated from the public regulatory record — FDA, CPSC, OEHHA (California Proposition 65), the FTC, and the U.S. Federal Register. Curated to surface the documents that meaningfully shape exposure, claim substantiation, and enforcement posture across cosmetics, personal care, and ingestible categories.
Sources · FDA Cosmetics · CPSC · Proposition 65 · Consumer Protection · Cosmetics · Toxic Substances · Hazardous Materials · Environmental Protection
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Read sourceEcosystem architecture
Authority
Independent scientific governance, toxicological evaluation, and regulatory interpretation — signed by a named toxicologist.
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Enterprise infrastructure
Enterprise toxicology intelligence infrastructure — exposure assessment, contaminant surveillance, and compliance documentation for brands and retailers.
toxintel.tagc.usConsumer distribution
Consumer-facing distribution layer of the broader Aᴳ ecosystem. Operated and positioned separately from enterprise infrastructure.
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